CD28 T Cells in an Antitumor Cell Attack
The T-cell–mediated antitumor immune response is frequently
repressed in the tumor environment by an immunologic
barrier, the predominant mediators of which are thought to
be interleukin-10 (IL-10) and transforming growth factor-B
(TGF-B). We explored the effect of these cytokines on the
individual T-cell effector functions on antigen engagement
during an antitumor cell attack. Isolated CD4+ and CD8+ T
cells were antigen-specifically redirected toward carcinoembryonic
antigen (CEA)-positive tumor cells by expression of a
recombinant T-cell receptor (immunoreceptor), which triggers
T-cell activation via CD3Z on binding to CEA. Immunoreceptor-
activated T cells secrete IFN-;, proliferate, and lyse
CEA+ but not CEA
tumor cells. Whereas IL-10 has no direct
effect on immunoreceptor-triggered effector functions, TGF-B
represses proliferation of both CD4+ and CD8+ T cells but
neither IFN-; secretion nor specific cytolytic activities. CD28
costimulation, however, overcomes TGF-B–mediated repression
in T-cell proliferation. Consequently, T cells redirected by
a combined CD28-CD3Z signaling immunoreceptor are largely
resistant to TGF-B–mediated repression. This is reflected
in vivo by a more pronounced antitumor activity of T cells
against TGF-B–secreting tumors when redirected by a
costimulatory CD28-CD3Z than by a CD3Z signaling immunoreceptor.
[Cancer Res 2007;67(5):2265–73]
Alternative cancer treatment options A quick overview of the main theories about cancer treatment with diet, vitamins, antioxidants and many others. Which cancer treatment options work the best, what to avoid, which natural cancer treatment options are completely worthless, which natural cancer treatment options can actually kill you!
Photodynamic Therapy for Leukemia This link goes into detail on leukemia treated with photodynamic therapy. Leukemia is one of those nasty cancers that attacks children and conventional leukemia treatments just cause suffering with little to no hope of long term survival. A more natural treatment for leukemia increases the odds of success and brings real hope to leukemia patients. Leukemia does respond to some herbal remedies to a certain degree, but to mount an immune response to leukemia it is necessary to kill most or at least some leukemia with photodynamic therapy to release the leukemia epitopes.
Alternative Treatment for Lung Cancer Provides details on a few past treatments of lung cancer with photodynamic therapy. Lung cancer responds well to photodynamic therapy, even when there are lung cancer mets in the bones, lung cancer mets in the brain and conventional medicine has completely given up on you, it is possible to recover completely from lung cancer with alternative treatments. Lung cancer requires several adjuvants, four of which are only available from us. We always have good success with Lung cancer using our more natural cancer treatment.
Treating Colon Cancer successfully Reports on past colon cancer treatments with Photodynamic Therapy. Colon cancer often goes to the inside wall of the abdomen, and in that case conventional treatment for colon cancer has already lost the battle. Colon cancer also likes to go the the liver, and conventional treatment for liver mets is hopeless, that is when honest oncologists admit there is nothing they can do for you. We can treat liver mets with a harmless drink more effectively than conventional treatment, and our success rate with colon cancer is much higher than conventional treatment could even dream of.
Breast Cancer treatments What to avoid in breast cancer pre-care, if at all possible. What is the role of photodynamic therapy in breast cancer? How to best detect breast cancer, which breast cancer detection programs are dangerous, which breast cancer detection systems are most reliable. Does alternative treatment for breast cancer work? What side effects are there for alternative breast cancer treatment? Does PDT work for post salvage chest wall progression of breast cancer?
Prostate Cancer When to consider treating prostate cancer and what NOT to do. Fantastic rapid response of prostate cancer to photodynamic therapy. Visit this link for a video from a patient who had prostate cancer for 16 years and tried all other alternatives to no avail, but his prostate was returned to normal four days after photodynamic therapy for prostate cancer. While prostate cancer is not among the more lethal cancers, it does kill a lot of people and makes even more have a poor quality of life due to prostate complications.
Pancreatic Cancer is difficult to beat, but not impossible. Statistically conventional treatment for pancreatic cancer has essentially zero percent success, but some alternatives do okay. Pancreatic cancer treatment with chemotherapy does not improve survival time at all. What natural pancreatic cancer treatments work, how they work and how much benefit is there to natural pancreatic cancer treatment. With conventional treatment pancreatic cancer survival is 6 months, but there are many people who took a natural alternative route and are alive many years later with no pancreatic cancer.
Cancer Therapy General observations on cancer treatment success. We go into detail on this page about how to sort out which type of photodynamic therapy has the best chance of success, and we discuss the sensitizers used on alternative cancer therapy. The sensitizer is 90% of the battle, and we clearly have the best sensitizer for alternative cancer therapy.
Cure Cancer Is it even possible to cure cancer? How do we define a cancer cure? The FDA comes down hard on anyone that even uses the words cure and cancer in the same paragraph, but that is because conventional cancer treatment does not cure cancer, in fact it propogates cancer and makes it worse. It is not impossible to cure cancer, but in my opinion the only true cure comes from mounting an immune response so the body can cure itself.
Osteosarcoma Osteosarcoma, (bone cancer) like leukemia, is one of those nasty diseases that attacks our children and steals their childhood. Osteosarcoma does not respond to surgery, it is just a patch to buy time but it actually spreads the osteosarcoma. Chemotherapy does not work with osteosarcoma if it is even slightly advanced. Fortunately, osteosarcoma can be beaten with alternative cancer treatment. When osteosarcoma goes metastatic it becomes more difficult to manage, but a full immune response to osteosarcoma is possible and then the immune system hunts down the remaining osteosarcoma cells throughout the body.
Liver Cancer Some liver cancer actually originates in the liver, that is the primary site. Most liver cancer is metastatic liver cancer, originating in other parts of the body. In either case, alternative treatment is far safer for liver cancer, because the liver specializes in removing toxins from the body, and nothing is more toxic than chemotherapy. Liver cancer can be treated with alternative treatments including activating the immune system against it by killing the primary site, and we can also treat it with stunningly effective natural treatments using safe medications that you drink, with no side effects. Liver cancer does not have to be a death sentence, you can beat liver cancer with our help.
Brain cancer Primary brain cancer originates in the brain like the super deadly glioblastoma, but many brain tumors are metastatic having come from lung cancer or prostate cancer or breast cancer. Essentially any cancer can migrate to the brain. The metastatic brain tumors can be killed with natural cancer treatment just like the primary brain tumors. Glioblastoma is another thing altogether, far more difficult to kill type of brain cancer but we can manage it using some very special medications only we have. Even years ago we were able to triple the survival time of brain cancer patients with a high quality of life, and with our new adjuvants we are seeing brain cancer results better than ever before.
|For an alternative view on the cause of cancer, click here|
|If you are doing research there are over 1,000 technical papers here|
Use the links below for an educational series on fourth generation PDT
PDT 1 PDT 2 PDT 3 PDT 4 PDT 5 PDT 6 PDT 7 PDT 8 PDT 9 PDT 10 PDT 11 Dr Garcia discussing treatmen with PDT in CebuInterview with prostate cancer patient Interview with lung cancer patient with brain and bone mets