Cyclooxygenase-2 (COX-2) plays a crucial role in Helicobacter pylori-associated gastric cancer. In this study, we report that H.
pylori-induced COX-2 expression enhances the cancer cell invasion and angiogenesis via TLR2 and TLR9, which can be attenuated
by the specific COX-2 inhibitor NS398 or celecoxib. The cAMP response element (CRE) and AP1 sites, but not B on the COX-2
promoter, are involved in MAPKs-regulated COX-2 expression. Differential bindings of the CREB-1, ATF-2, c-jun to the CRE site,
and the c-fos, c-jun, ATF-2 to the AP1 site are demonstrated by DNA affinity protein-binding, supershift, and chromatin immunoprecipitation
assays. Activations of these transcription factors were attenuated by different MAPKs inhibitors. The mutants of
TLR2, TLR9, or MAPKs inhibited H. pylori-induced COX-2 promoter, CRE, and AP-1 activities. MAPKs inhibitors attenuated
the H. pylori-induced COX-2 mRNA and protein expressions. These results indicate that H. pylori acts through TLR2 and TLR9
to activate MAPKs, especially p38, and their downstream transcription factors (CREB-1, ATF-2, c-jun, and c-fos), resulting in the
activations of CRE and AP-1 on the COX-2 promoter. These intracellular networks drive the COX-2-dependent PGE2 release and
contribute to cell invasion and angiogenesis. The Journal of Immunology, 2005, 175: 8242–8252.
Alternative cancer treatment options A quick overview of the main theories about alternative cancer treatment with diet, vitamins, antioxidants and many others. Which alternative cancer treatment options work the best, what to avoid, which alternative cancer treatment options are completely worthless, which alternative cancer treatment options can actually kill you!
Photodynamic Therapy for Leukemia This link goes into detail on leukemia treated with photodynamic therapy. Leukemia is one of those nasty cancers that attacks children and conventional leukemia treatments just cause suffering with little to no hope of long term survival. Alternative cancer treatment for leukemia increases the odds of success and brings real hope to leukemia patients.
Alternative Treatment for Lung Cancer Provides details on a few past treatments of lung cancer with photodynamic therapy. Lung cancer responds well to photodynamic therapy, even when there are lung cancer mets in the bones, lung cancer mets in the brain and conventional medicine has completely given up on you, it is possible to recover completely from lung cancer with alternative treatments. Lung cancer requires several adjuvants, four of which are only available from us. We always have good success with Lung cancer using our alternative cancer treatment.
Treating Colon Cancer successfully Reports on past colon cancer treatments with Photodynamic Therapy. Colon cancer often goes to the inside wall of the abdomen, and in that case conventional treatment for colon cancer has already lost the battle. Colon cancer also likes to go the the liver, and conventional treatment for liver mets is hopeless, that is when honest oncologists admit there is nothing they can do for you. We can treat liver mets with a harmless drink more effectively than conventional treatment, and our success rate with colon cancer is much higher than conventional treatment could even dream of.
Breast Cancer treatments What to avoid in breast cancer pre-care, if at all possible. What is the role of photodynamic therapy in breast cancer? How to best detect breast cancer, which breast cancer detection programs are dangerous, which breast cancer detection systems are most reliable. Does alternative treatment for breast cancer work? What side effects are there for alternative breast cancer treatment?
Prostate Cancer When to consider treating prostate cancer and what NOT to do. Fantastic rapid response of prostate cancer to photodynamic therapy. Visit this link for a video from a patient who had prostate cancer for 16 years and tried all other alternatives to no avail, but his prostate was returned to normal four days after photodynamic therapy for prostate cancer.
Pancreatic Cancer is difficult to beat, but not impossible. Statistically conventional treatment has essentially zero percent success, but some alternatives do okay. Pancreatic cancer treatment with chemotherapy does not improve survival time at all. What Alternative pancreatic cancer treatments work, how they work and how much benefit is there to alternative pancreatic cancer treatment.
Cancer Therapy General observations on cancer treatment success. We go into detail on this page about how to sort out which type of photodynamic therapy has the best chance of success, and we discuss the sensitizers used on alternative cancer therapy. The sensitizer is 90% of the battle, and we clearly have the best sensitizer for alternative cancer therapy.
Cure Cancer Is it even possible to cure cancer? How do we define a cancer cure? The FDA comes down hard on anyone that even uses the words cure and cancer in the same paragraph, but that is because conventional cancer treatment does not cure cancer, in fact it propogates cancer and makes it worse.
Osteosarcoma Osteosarcoma, (bone cancer) like leukemia, is one of those nasty diseases that attacks our children and steals their childhood. Osteosarcoma does not respond to surgery, it is just a patch to buy time but it actually spreads the osteosarcoma. Chemotherapy does not work with osteosarcoma if it is even slightly advanced. Fortunately, osteosarcoma can be beaten with alternative cancer treatment.
Liver Cancer Some liver cancer actually originates in the liver, that is the primary site. Most liver cancer is metastatic cancer, originating in other parts of the body. In either case, alternative treatment is far safer for liver cancer, because the liver specializes in removing toxins from the body, and nothing is more toxic than chemotherapy. Liver cancer can be treated with alternative treatments including activating the immune system against it by killing the primary site, and we can also treat it with stunningly effective alternative treatments using safe medications that you drink, with no side effects.
Brain cancer Brain cancer can originate in the brain like the super deadly glioblastoma, or it can be metastatic having come from lung cancer or prostate cancer or breast cance.. essentially any cancer can migrate to the brain like it migrates anywhere else. The metastatic tumors can be killed with alternative cancer treatment just like the primary tumors. Glioblastoma is another thing altogether, far more difficult to kill but we can manage it using some very special medications only we have.
|For an alternative view on the cause of cancer, click here|
|If you are doing research there are over 1,000 technical papers here|
Use the links below for an educational series on fourth generation PDT
PDT 1 PDT 2 PDT 3 PDT 4 PDT 5 PDT 6 PDT 7 PDT 8 PDT 9 PDT 10 PDT 11 Dr Garcia discussing treatmen with PDT in CebuInterview with prostate cancer patient Interview with lung cancer patient with brain and bone mets